Urine NT-ProBNP in Neonatal Respiratory Distress

The Prognostic Value of Urine NT-ProBNP in Neonatal Respiratory Distress

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02020993

Acronym

NT-proBNP

Enrollment

150

Registered

2013-12-27

Start date

2013-12-31

Completion date

2015-01-31

Last updated

2014-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal Respiratory Distress

Keywords

Nt-proBNP, newborn, preterm

Brief summary

There is a need for a biochemical marker in addition to clinical condition which will help the physician to understand the clinical progress of the disease. Urine Nt-proBNP, which does not need any blood sampling and can be collected easily, has not been evaluated for respiratory distress in newborn. The investigators aim to evaluate the prognostic value of urine NT-proBNP in respiratory diseases in newborns by a controlled trial.

Detailed description

Neonatal diseases such as respiratory distress and transient tachypnea of newborn may require high level of intensive care. On the other hand, some minor difficulties in respiration can resolve within hours. Therefore, there is a need for a biochemical marker in addition to clinical condition which will help the physician to understand the clinical progress of the disease. Serum NT-ProBNP level has been evaluated in transient tachypnea of newborn and found compatible with the clinical progress. Urine NT-proBNP has recently been evaluated in patent ductus arterioses and found compatible with the cardiac progress. However, urine Nt-proBNP, which does not need any blood sampling and can be collected easily, has not been evaluated for respiratory distress in newborn. The investigators aim to evaluate the prognostic value of urine NT-proBNP in respiratory diseases in newborns by a controlled trial.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Days to 7 Days

Healthy volunteers

Yes

Inclusion criteria

* study group; newborns who are admitted to the neonatal intensive care unit within first 2 days of life and have transient tachypnea of newborn or respiratory distress syndrome signed informed consent form * Control Group: Newborns without any respiratory distress

Exclusion criteria

* any cardiac anomaly sepsis acute renal insufficiency syndromic cases low APGAR score at 5th minute (\<7) lung malformations no informed consent inability in collection of urine

Design outcomes

Primary

Measure	Time frame	Description
severity of respiratory distress	7 days	Severity of respiratory distress will be evaluated by requirement of supportive treatment such as continuous positive airway pressure, need of intubation, mechanical ventilation and duration of support (hours)

Countries

Turkey (Türkiye)

Contacts

Primary ContactDuran Yildiz, MD

doktorduranyildiz@hotmail.com+903125957459

Outcome results