Endocrine System Diseases
Conditions
Brief summary
The objective of this study is to examine ghrelin, amylin, glucagon and glucagon-like peptide (GLP)-1 responses to a test meal in lean and obese individuals.
Detailed description
The primary hypothesis is that obese adolescents have a disturbed balance of hormones associated with appetite regulation with less suppression of ghrelin and attenuated stimulation of GLP-1 secretion in response to meal intake compared to lean normal weight controls. A second aim of the study was to test which gastrointestinal peptides are most associated with insulin resistance.
Interventions
DIETARY_SUPPLEMENTtest meal (500 kcal)
whole wheat bread (68 g), butter(10 g), ham (25 g); chocolate cream (90 g); orange juice (200 mL)
Sponsors
University Children's Hospital Basel
University Hospital, Basel, Switzerland
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
11 Years to 16 Years
Healthy volunteers
Yes
Inclusion criteria
* caucasian youth * pubertal Tanner stage x, y, or z
Exclusion criteria
* fasting plasma glucose \> 7.0 mmol/L * significant illness * taking medications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of gastrointestinal peptide secretion in normal weight and obese adolescents | 2 hours blood sampling | Relation of GLP-1 release to insulin secretion in normal weight and obese adolescents |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association between gastrointestinal peptides and insulin release | 2 hours blood sampling | Dynamics of gastrointestinal peptide secretion including Tmax and Cmax |
Countries
Switzerland
Outcome results
None listed