Hyperkalemia
Conditions
Keywords
drug interactions, Drug Monitoring, Potassium, Hyperkalemia
Brief summary
To investigate the impact of reminders for serum potassium monitoring and of hyperkalemia alerts during potassium-increasing drug-drug-interactions.
Detailed description
The development of hyperkalemia during potassium-increasing drug-drug-interactions (DDIs) is associated with (i) unknown or elevated serum potassium level at onset of treatment and (ii) insufficient monitoring of serum potassium during therapy. However, potassium-increasing DDIs are frequently started despite an unknown or elevated serum potassium level, and monitoring intervals often exceed 48 hours. This study investigates the impact of reminders for serum potassium monitoring and hyperkalemia alerts. Both reminders and alerts are displayed in the electronic patient chart of in-patients treated with potassium-increasing DDIs.
Interventions
BEHAVIORALdecision support in potassium-inc. drug-drug-interactions
display of computer-based reminders for serum potassium monitoring and hyperkalemia alerts
Sponsors
University of Zurich
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* in-patients treated with concurrent potassium-increasing drugs
Exclusion criteria
* outpatients; in-patients on wards without computerized physician order entry (i.e. patients treated in the ICU)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Impact on serum potassium monitoring during potassium-increasing drug-drug-interactions | 1 year | Rate of serum potassium monitoring intervals of \< = 72 hours during potassium-increasing drug-drug-interactions in proportion to all serum potassium monitoring intervals during potassium-increasing drug-drug-interactions |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of potassium-increasing drug-drug-interactions ordered in the presence of hyperkalemia | 1 year |
| Frequency of transfers to the ICU during potassium-increasing drug-drug-interactions in function of the serum potassium level | 1 year |
| Frequency of hyperkalemia during potassium-increasing drug-drug-interactions | 1 year |
| Change in frequency distribution of serum potassium monitoring intervals | 1 year |
| Response of physicians to the computer-based alerts and reminders | 1 year |
| Frequency of death during potassium-increasing drug-drug-interactions in the presence or absence of hyperkalemia | 1 year |
Countries
Switzerland
Outcome results
None listed