Antioxidant Effect of Aged Garlic Extract

A Randomized, Double-blind, Placebo Controlled, Crossover Study to Evaluate the Antioxidant Effect of Aged Garlic Extract in Heavy Smokers

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02019368

Enrollment

Registered

2013-12-24

Start date

2013-11-30

Completion date

2015-04-30

Last updated

2015-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heavy Smoker or Non-smoker

Brief summary

This is a randomized, double-blind, placebo controlled, crossover study to determine the antioxidant effect of aged garlic extract. This study will also compare the oxidative status in heavy smokers with that in non-smokers.

Interventions

DIETARY_SUPPLEMENTPlacebo

DIETARY_SUPPLEMENTAged garlic extract

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

40 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Smoking (at least 20 cigarettes per day) or non-smoking (more than 20 years)

Exclusion criteria

* Under medication for chronic disease * Garlic allergy * Engaging in vigorous exercise * Taking drugs or functional food that may possess antioxidant property * Participation in any clinical trial within 90 days of the commencement of the trial * Renal or hepatic dysfunction * Heart disease

Design outcomes

Primary

Measure	Time frame
Urinary 8-hydroxydeoxyguanosine (8-OHdG)	Every 4 weeks (Overall 12 weeks)

Secondary

Measure	Time frame
High sensitive CRP	Every 4 weeks (Overall 12 weeks)
Blood pressure	Every 4 weeks (Overall 12 weeks)
Indices of the second derivative of photoplethysmogram (SDPTG)	Every 4 weeks (Overall 12 weeks)

Countries

Japan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026