Obsessive-Compulsive Disorder
Conditions
Keywords
Obsessive-Compulsive Disorder, Attention Training, Attention Bias Modification, Dot-Probe Task, Randomized Controlled Trial, Online Treatment, Washing, Checking
Brief summary
The goal of this study is to investigate an attention training program for participants with Obsessive-Compulsive Disorder. The attention training consists of a modified dot probe task with picture stimuli related to washing and checking paired with neutral pictures. Participants are randomly assigned to an experimental and a placebo-control group. After a minimum of 4 weeks of attention training we expect to find differences between participants of the experimental and the control group in terms of attention bias, OCD symptoms, anxiety and depression.
Interventions
BEHAVIORALAttention Training Program
Sponsors
Humboldt-Universität zu Berlin
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* diagnosis of primary OCD according to OCI-R self report (cut-off \>=18)
Exclusion criteria
* suicidal * substance abuse or addiction * psychotic symptoms * visual impairment if not compensated with optical aid Current treatment is not an exclusion criterion, but data on treatment status (current psycho- or pharmacotherapy for OCD) will enter our statistical analyses.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Yale-Brown Obsessive-Compulsive Scale Self-Report Scale (Y-BOCS-SRS) T1 | pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set) | The Y-BOCS-SRS measures severity of OCD symptoms. |
| Yale-Brown Obsessive-Compulsive Scale Self-Report Scale (Y-BOCS-SRS) T2 | post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set) | The Y-BOCS-SRS measures severity of OCD symptoms. |
| Yale-Brown Obsessive-Compulsive Scale Self-Report Scale (Y-BOCS-SRS) T3 | follow-up, between day 27 and 50 after T2 questionnaires (time limit set) | The Y-BOCS-SRS measures severity of OCD symptoms. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Obsessive-Compulsive Inventory-Revised (OCI-R) T1 | pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set) | The OCI-R measures severity of OCD symptoms. |
| Obsessive-Compulsive Inventory-Revised (OCI-R) T2 | post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set) | The OCI-R measures severity of OCD symptoms. |
| Obsessive-Compulsive Inventory-Revised (OCI-R) T3 | follow-up, between day 27 and 50 after T2 questionnaires (time limit set) | The OCI-R measures severity of OCD symptoms. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Attention bias towards OCD-relevant stimuli at T1 measured with a dot-probe task. | after T1 questionnaires and pre-treatment, estimated: between day 1 and 3 after T1 questionnaires (no time limit set) | Attention bias is measured using a dot-probe task. In this task pairs of pictures (OCD-relevant/neutral) are presented briefly on a computer screen. Next, a probe randomly appears on one of the two former picture locations. Participants have to react to that probe by pressing the corresponding button on the keyboard. Attention bias is calculated as the mean difference in reaction times between trials in which the probe appears at the OCD-relevant location vs. trials in which it appears at the neutral location. The bias assessment session is masked as first training sessions in both groups. |
| Beck Depression Inventory II (BDI-II) T3 | follow-up, between day 27 and 50 after T2 questionnaires (time limit set) | The BDI measures severity of depressive symptoms. |
| Attention bias towards OCD-relevant stimuli at T2 measured with a dot-probe task. | post-treatment, after a minimum of 8 training sessions over a time of 4 weeks, estimated: between day 1 and 4 after last training session (no time limit set) | Attention bias is measured using a dot-probe task. In this task pairs of pictures (OCD-relevant/neutral) are presented briefly on a computer screen. Next, a probe randomly appears on one of the two former picture locations. Participants have to react to that probe by pressing the corresponding button on the keyboard. Attention bias is calculated as the mean difference in reaction times between trials in which the probe appears at the OCD-relevant location vs. trials in which it appears at the neutral location. |
| Beck Anxiety Inventory (BAI) T1 | pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set, all further steps relative to exact time point of T1 questionnaires) | The BAI measures severity of anxiety symptoms. |
| Beck Anxiety Inventory (BAI) T2 | post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set) | The BAI measures severity of anxiety symptoms. |
| Beck Anxiety Inventory (BAI) T3 | follow-up, between day 27 and 50 after T2 questionnaires (time limit set) | The BAI measures severity of anxiety symptoms. |
| Beck Depression Inventory II (BDI-II) T1 | pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set, all further steps relative to exact time point of T1 questionnaires) | The BDI measures severity of depressive symptoms. |
| Beck Depression Inventory II (BDI-II) T2 | post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set) | The BDI measures severity of depressive symptoms. |
Countries
Germany
Outcome results
None listed