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Single Application of Desensitizing Pastes as Dentin Sensitivity Treatment

Clinical Evaluation of the Effectiveness of Immediate Relief Obtained With Desensitizing Creams - A Controlled, Randomized, Triple Masked, Split-Mouth Clinical Trial

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02018783
Enrollment
138
Registered
2013-12-23
Start date
2013-04-30
Completion date
2013-08-31
Last updated
2013-12-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentine Hypersensitivity

Brief summary

The aim of this study was to evaluate the efficacy of three desensitizing toothpastes for immediate and intermediate-term relief of CDH, when compared with a control toothpaste. One hundred and thirty-eight hypersensitive teeth were diagnosed and randomized into four groups according to the therapeutic agent of each desensitizing cream tested: 1) strontium acetate and calcium carbonate, 2) calcium carbonate and arginine 8%, 3) calcium phosphate nanoparticles and 4) a control toothpaste. The desensitizing creams were applied according to the manufacturer's instructions. Cervical dentin hypersensitivity was assessed at baseline, immediately, 24 hours and 30 days after the treatment. Cold and evaporative tests were used to assess the sensitivity level.

Interventions

PROCEDUREColgate

Slow-speed handpiece with a Robson brush for 3 seconds by repeating the procedure

PROCEDURESensodyne

Digital application for 60 seconds.

PROCEDURENano P

Slow-speed handpiece with a Robson brush for 10 seconds

PROCEDURECocorico

Digital application for 60 seconds

Sponsors

Federal University of São Paulo
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender
ALL
Age
22 Years to 48 Years
Healthy volunteers
Yes

Inclusion criteria

* subjects 18 years or older * in good general and oral health; have complaint of CDH in teeth distributed in all 4 quadrants * not making use of desensitizing agents * not having undergone periodontal treatment over the past 3 months * respond to evaporative stimulus with a score ≥ 1.5 cm on VAS

Exclusion criteria

* patients who presented restorations and caries near the exposed dentin of the hypersensitive teeth * who made frequent use of painkillers, anti-inflammatory and antidepressants drugs

Design outcomes

Primary

MeasureTime frameDescription
cervical dentin hypersensitivity30 daysThe cervical dentin hypersensitivity was evaluated by an air blast (evaporative stimulus) for 5 seconds, and by a tetrafluoroethane spray (cold stimulus) for 5 seconds.

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026