An Explorative Prospective Observational Study to Describe Morphokinetic De-selection Parameters in Human Embryos

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02018159

Enrollment

738

Registered

2013-12-23

Start date

2014-01-31

Completion date

2016-05-12

Last updated

2017-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Brief summary

This post-marketing, multi-center prospective study will be conducted in a open-label, non-interventional setting, for women seeking fertility treatment and will describe morphokinetic de-selection parameters in human embryos.

Interventions

DRUGmenotropin

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

21 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Age 21-45 years * In Vitro Fertilisation/Intra Cytoplasmic Sperm Injection treatment in long or short protocol * Receiving follicle stimulation with Menopur 600/1200 IU

Design outcomes

Primary

Measure	Time frame
Incidence of direct cleavage from 1 to 3 and from 2 to 5 cells	1 week after oocyte retrieval
Incidence of uneven blastomeres at the 2 and 4 cell stage	1 week after oocyte retrieval
Incidence of bi- and multinucleation at 2 cell and 4 cell stage	1 week after oocyte retrieval
Incidence of Smooth Endoplasmatic Reticulum at the Metaphase II stage, the Pro Nuclei stage and the 2, 3 and 4 cell stage	1 week after oocyte retrieval

Secondary

Measure	Time frame
Positive serum human Chorion Gonadotrophin (hCG) rate	13-15 days after transfer
Live birth rate	9 months
Implantation rate	5 weeks after transfer
Clinical pregnancy rate	7 weeks after transfer
Ongoing pregnancy rate	10 weeks after transfer

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026