Establishing the Central and Peripheral Fatigue Indexes and VR Based Anti-fatigue Training Paradigm for Individuals With Parkinson Disease

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02017938

Enrollment

Registered

2013-12-23

Start date

2014-12-10

Completion date

2016-07-31

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease (PD)

Keywords

Fatigue, electromyography (EMG), central fatigue, cycling training

Brief summary

Fatigue is one of the most common symptoms in individuals with Parkinson's Disease (PD). Past researches indicated that more than half of the individuals with PD demonstrated fatigue symptom. The severity of fatigue was also correlated to the quality of life in individuals with PD. Finding the contributions of the central and the peripheral factors to fatigue, building reliable fatigue indexes, and developing an effective training program for individuals with PD are very important. The purpose of this project is to develop non-invasive method to monitor central and peripheral fatigue, to establish Virtual Reality(VR) anti-fatigue ergo cycling training paradigm, and to evaluate the long term training effect in individuals with PD.

Interventions

PROCEDUREVirtual Reality anti-fatigue ergo cycling training (Self-made)

To establish a Virtual Reality systems to reduce fatigue of cycling training for PD subjects.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosis of Parkinson disease * Hoehn and Yahr ≦3

Exclusion criteria

* Musculoskeletal injuries * Osteoporosis * Diabetes * Any peripheral or central nervous system injury or disease patients

Design outcomes

Primary

Measure	Time frame	Description
Muscle twitch force	baseline, 1 week	Measure of changes in muscle twitch force by interpolation twitch technique.
Muscle voluntary activity level	Baseline,1 week	Measure of changes in muscle voluntary activity level by interpolation twitch technique.
Heart rate/Heart rate variability	Baseline,1 week	Measure of changes in Heart rate/Heart rate variability.
Borg's rate of perceived exertion	Baseline,1 week	Measure of changes in Borg's rate of perceived exertion.

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026