Behavior and Behavior Mechanisms
Conditions
Keywords
zeaxanthin, visual function, reaction time, processing speed
Brief summary
This study was designed to test whether two zeaxanthin formulations (supplements containing different nutritional compounds with zeaxanthin and omega fatty acids being the primary ingredients of interest) influenced visual motor function. Visual motor function refers to the processing speed of the visual system and how individuals respond behavioral to visual stimuli (e.g., reaction time).
Detailed description
This study was designed to test whether two zeaxanthin formulations (supplements containing different nutritional compounds with zeaxanthin and omega fatty acids being the primary ingredients of interest) influenced visual motor function. Visual motor function refers to the processing speed of the visual system and how individuals respond behavioral to visual stimuli (e.g., reaction time).
Interventions
DIETARY_SUPPLEMENTzeaxanthin
softgel
DIETARY_SUPPLEMENTcombinatory supplement
softgel
Sponsors
ZeaVision, LLC
University of Georgia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Age: ≥18 and ≤ 40 years * BMI: ≥ 20 and ≤ 30 kg/m2 * No anticipated changes in dieting habits (as relevant to the intake of xanthophylls and fats/oils). * No anticipated surgical procedures. * Willingness and ability to give written informed consent and willingness and ability to comply with the study requirements. * Corrected visual acuity (ETDRS): better than 20/60 in the eye selected for the study
Exclusion criteria
* Smokers * Current or history of relevant ocular diseases (such as AMD) or other conditions e.g., lipid disorders. * Inability to reliably perform macular pigment optical density measurements by Heterochromatic Flicker Photometry or any of the other ophthalmic tests of the study. * Any condition likely to interfere with normal gastro-intestinal absorption of xanthophylls (e.g., digestive disorders: inflammatory bowel disease, ulcerative colitis, Crohn's, irritable bowel, etc. or lipid disorders including conditions such as hypercholesterolemia) * Current use of xanthophyll containing supplements or use of xanthophyll containing supplements in the past 6 months (but excluding multivitamins containing lutein or zeaxanthin at low potency). * Participation in any other study during last 1 month before study initiation. * Known hypersensitivity or allergy to xanthophylls. * Regular intake of medications or supplements, which the principal investigator deems likely to confound the study outcomes. These include diabetes medication and statins or any other drug/supplement to modulate cholesterol or fat digestion/absorption.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Macular pigment optical density | one year | Increases in the amount of macular pigment measured in optical density units |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| coincidence anticipation | 12-months | button press when a light stimulus of varying speeds reaches a specific point in a linear light array |
| fixed reaction time | one year | reaction time to a stimulus fixed in space |
| variable reaction time | 12-months | reaction time to a stimulus with a position that varies in space |
Countries
United States
Outcome results
None listed