Esophageal Cancer
Conditions
Keywords
Surgery, Malnutrition, Nutrition, Enteral
Brief summary
It is well known that there is a considerable postoperative weight loss in patients undergoing esophageal resection for cancer. We believe that this weigh loss can be limited by administering postoperative enteral feeding (target: 1000 kCal/ day) via feeding jejunostomy for at least 6 weeks postoperatively. We hypothesize that patients undergoing esophageal resection for cancer will have a better overall survival with postoperative additional enteral feeding than when on regular oral diet alone.
Interventions
OTHEREnteral feeding
Target of 1000 kCal/day enteral feeding or glucose 20%, perferably given overnight.
Sponsors
University Hospital, Gasthuisberg
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* advanced cT2 N+ or cT3 Nx * all histology * GEJ or distal esophageal ACC * proximal or mid SCC * curative intent with intention to treat * no M+ * at least two-field lymphadenectomy * all access: MIE, left thoraco freno or R thoraco + laparotomy with intrathoracic or cervical anastomosis * all anastomosis (intrathoracic, cervical)
Exclusion criteria
* T4 * R2 * transhiatal * pt in definitive CRT or rescue resection following definitive CRT * palliative treatment * tumours in cervical esophagus * pharyngeal cancer with gastric pull-up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| overall survival from day of surgery | 5 years postoperative | overall survival at 5 years after esophagectomy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| postoperative weight loss | 1 year after surgery | weight loss will be calculated by using age- and gender corrected BMI percentiles |
Countries
Belgium
Outcome results
None listed