Glucocorticoid Induced Hyperglycemia
Conditions
Brief summary
Glucocorticoids therapy exposes the patient to an increased risk for diabetes morbidity. However, there is no proven preventive therapy. GLP-1-RA has shown to improve glucose metabolism in healthy volunteers treated with glucocorticoids. We assume that GLP-1-RA will improve glucose metabolism in patients with high risk for diabetes morbidity, treated with glucocorticoids.
Interventions
DRUGLiraglutide
DRUGPlacebo
Sponsors
Rabin Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Planned treatment with T. Prednisone in dosage \>0.5 mg/kg for two weeks or more. * Age \>18 years * Body mass index \>27 kg/m2 OR 1st degree relative with type 2 diabetes mellitus OR hypertension OR hyperlipidemia OR gestational diabetes in the past OR diagnosis of polycystic ovary syndrome.
Exclusion criteria
* Glycosylated hemoglobin A1c \>6.5% * Diagnosis of diabetes mellitus or treatment with anti-glycemic drug * Pancreatitis (acute or chronic) in the past * Active malignancy * Medullary thyroid carcinoma or multiple endocrine neoplasm type 2 of the patient or of 1st degree relative * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glucose levels 2 hours after 75 gr OGTT | 6 weeks |
Countries
Israel
Contacts
Primary ContactAmit Tirosh, MD
Outcome results
None listed