Respiratory Aspiration of Gastric Contents
Conditions
Brief summary
Gastro-esophageal reflux and aspiration is a common problem in premature infants receiving mechanical ventilation. Pepsin measured in tracheal aspirate (TA) emerged as a specific marker for aspiration. The objective of this study is to examine if TA pepsin will change when ventilated premature infants are positioned in two different positions; on their back vs. on their right side.
Interventions
BEHAVIORALRight side position
Enrolled infants are positioned on their back or right side. Tracheal aspirate is assessed for pepsin concentration as an index of aspiration.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
3 Days to 28 Days
Healthy volunteers
No
Inclusion criteria
* Infants born between 28 and 32 weeks gestational age * postnatal age \> 72 hours * tracheally intubated and receiving conventional mechanical ventilation * feeding enterally more than 20 ml per day.
Exclusion criteria
* neurological insult in the form of perinatal asphyxia (pH \<7, base deficit more than 12, Apgar score at \< 3 at 5 minutes of life), intracranial hemorrhage grades 3 or 4 at 72 hours of age or periventricular leucomalacia * major congenital anomalies, or gastrointestinal anomalies such as tracheoesophageal fistula, or necrotizing enterocolitis , * receiving xanthine derivatives, H2 blockers, prokinetics, proton pump inhibitors or sedation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pepsin concentration in tracheal aspirate | 6 hours after intervention |
Countries
Egypt
Outcome results
None listed