Hypertension
Conditions
Keywords
blood pressure, sodium, salt, low sodium high potassium salt, potassium, Vietnam, randomized controlled trial
Brief summary
The purpose of this study was to investigate the effects of low-sodium, high-potassium condiments and salt on blood pressure in untreated (pre)hypertensive Vietnamese adults.
Interventions
OTHERLow-sodium, high-potassium salt
Iodized low-sodium, high-potassium botcanh (a traditional mixture of salt, MSG, sugar and herbs) plus and iodized low-sodium, high-potassium salt for home food preparation
OTHERRegular salt
Regular iodized high-sodium botcanh (a traditional mixture of salt, MSG, sugar and herbs) and high-sodium salt
Sponsors
National Institute of Nutrition, Vietnam
Wageningen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
45 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
Untreated prehypertension or mild hypertension (systolic BP between 130 and 160 mmHg and/or diastolic BP between 85 and 100 mmHg) based on the mean of two measurements with a 1-week interval
Exclusion criteria
Diagnosed or self-reported cardiovascular disease Diagnosed or self-reported kidney disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in office systolic blood pressure (SBP) | Change during 8 weeks of intervention | Based on repeated measurements with a digital BP device (OMRONHEM 762) using the standard protocol of WHO STEP guideline at week 0, 2, 4 6 and 8. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in office diastolic blood pressure (DBP) | Change during 8 weeks of intervention | Based on repeated measurements with a digital BP device (OMRONHEM 762) using the standard protocol of WHO STEP guideline at week 0, 2, 4, 6 and 8. |
Other
| Measure | Time frame |
|---|---|
| Change in body weight | Change during 8 weeks of intervention |
| Change in 24-hour urinary calcium excretion | Change during 8 weeks of intervention |
| Change in 24-hour urinary iodine excretion | Change during 8 weeks of intervention |
| Change in 24-hour urinary sodium excretion | Change during 8 weeks of intervention |
| Change in 24-hour urinary protein | Change during 8 weeks of intervention |
| Change in heart rate | Change during 8 weeks of intervention |
| Change in 24-hour urinary creatinine excretion | Change during 8 weeks of intervention |
| Change in 24-hour urinary potassium excretion | Change during 8 weeks of intervention |
Countries
Vietnam
Outcome results
None listed