Elderly Patients, Esophageal Squamous Cell Cancer
Conditions
Brief summary
Elderly patients with metastatic esophageal squamous cell carcinomas have poor prognosis and majority of them were intolerable to combined chemotherapy in China. In the investigators phase II clinical trial proceeded before, the paclitaxel treatment showed good tolerance and efficacy to esophageal squamous cell carcinomas. Radiotherapy has been indicated as a definitive treatment for unresectable or medically inoperable tumors in ESCC patients. However, not only the combination with chemotherapy, but also the boundaries of the clinical target volume (CTV) are not internationally defined. The investigators then initiated a prospective phase II clinical trial with sequential paclitaxel/cisplatin and radiotherapy as the 1st line treatment in elderly metastatic esophageal carcinoma to observe the efficacy and safety of the combination.
Interventions
OTHERSequential chemotherapy （paclitaxel 80mg/m2 d1,d8) and radiotherapy
Sequential paclitaxel chemotherapy and radiotherapy
Sponsors
Shen Lin
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
69 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Having signed informed consent Age more than 69 years old 2. Histologically confirmed esophageal squamous carcinoma,metastatic disease with primary tumor,no prior palliative chemotherapy; 3. No prior radiotherapy except radiotherapy at non-target lesion of the study more than 3 months 4. Sex is not limited 5. Measurable disease according to the RECIST criteria(diameter of the lesion should be more than 10mm by spiral CT or MRI, more than 20mm by common CT, the date of image should be less than 15 days before enrollment) 6. Karnofsky performance status ≥80 7. Life expectancy of ≥ 3 month 8. WBC \> 3,000/mm3, absolute neutrophil count ≥2000/mm3, platelet \> 100,000/mm3, Hb \> 9g/dl(within 14 days before enrollment),ALT and AST \< 1.5 times ULN (≤5 times ULN in patients with liver metastases),Bilirubin level \< 1.0 times ULN,Serum AKP \< 2.5 times ULN,Serum creatinine \< 1.0 times ULN 9. No sever complication, such as active gastrointestinal bleeding, perforation, jaundice, obstruction, non-cancerous fever \> 38℃； 10. Normal ECG and heart function 11. Fertile patients must use effective contraception Good compliance
Exclusion criteria
1. Previous treatment of palliative chemotherapy 2. Known hypersensitivity to Paclitaxel,Cisplatin 3. Only with Brain or bone metastasis 4. No measurable lesions, eg. pleural fluid and ascites 5. Suffer from severe heart disease or disease with other important organs Chronic diarrhea or renal dysfunction 6. Other previous malignancy within 5 year, except non-melanoma skin cancer 7. Mentally abnormal or disable cognition,including CNS metastasis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| progression free survival | 1 year | the follow-up visit of PFS will be performed every 2 cycles |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| overall survival | 2 years | OS means that from the first dose of treatment drug to death or lost, the follow-up visit will be performed every 3 months till death or lost |
Other
| Measure | Time frame |
|---|---|
| disease control rate | 1 year |
| adverse events | 2 years |
| quality of life | 2 years |
Countries
China
Contacts
Primary ContactLin Shen, MD
Backup ContactZhihao Lu, MD
Outcome results
None listed