PWV for Cardiovascular Complication After Cardiac Surgery

Evaluation of Pulse Wave Velocity as a Predictive Factor for Postoperative Cardiovascular Complication After Cardiac Surgery: a Prospective Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02014012

Enrollment

Registered

2013-12-17

Start date

2013-04-30

Completion date

2014-11-30

Last updated

2015-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C.Surgical Procedure; Cardiac

Brief summary

Arterial stiffness has been suggested as an independent risk factor for the development of coronary artery disease and stroke. Pulse wave velocity (PWV) is an noninvasive established index to quantify arterial stiffness. Therefore, we try to investigate the correlation between PWV values and cardiovascular complications like stroke, acute renal failure, or perioperative myocardial infarction after cardiac surgery.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

* Cardiac surgery patients who sign the informed consent

Exclusion criteria

* Chronic renal failure (Cr\>1.5mg/dL), Dialysis patients * Previous stroke * Left ventricular dysfunction (EF \<50%) * ASO with claudication * \< 40 years

Design outcomes

Primary

Measure	Time frame	Description
Postoperative cardiovascular complication and parameters	within the first 7 days after surgery	Stroke, Delirium, Newly developed atrial fibrillation, ARF, Peak CK-MB and troponin I levels measured at 12 and 24 hours after surgery, Peak estimated GFR and corresponding creatinine

Secondary

Measure	Time frame	Description
E/e' and e' measured by transthoracic echocardiography with color-coded tissue dopper imaging in patients undergoing non-valvular cardiac surgery	baseline and within the first 14 days after surgery	peak early transmitral filling velocity during early diastole (E), mean early velocity at the septal mitral annulus (e')

Countries

South Korea

Outcome results