Low Flow Anaesthesia, is There a Difference Between 2 Modern Anaesthetic Machines Using Different Gas Reservoir

Low Flow Anaesthesia; Cost-effectiveness of the Flow-I Anaesthesia Machine, a Comparison to Established Anaesthesia Delivery Unit

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02013869

Acronym

Enrollment

Registered

2013-12-17

Start date

2015-05-31

Completion date

2017-08-31

Last updated

2024-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General Anaesthesia

Keywords

fresh gas flow, quality of anaesthesia, minimal alveolar concentration

Brief summary

To study the Flow-I breathing circle during low flow general anaesthesia, whether this non-below system has advantages reduced time to reach Et 1MAC (minimal alveolar concentration) and lower consumption of inhaled agent

Detailed description

Assessing whether there are clinical differences in anaesthetic performance between standard anaesthesia workstation including a below and the new Flow-I device without a below

Interventions

DEVICEFlow-I, a modern anaesthetic machine without a bag/below/gas reservoir for compression of insufflation gas

Desflurane Dialed setting 18 % on the machine gas vaporized

DEVICEAsys, a anaesthetic machine with a bag/bellow for compression of gas to be insufflated

Desflurane dialed 18% on the machine gas vaporized

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Investigator)

Intervention model description

We studied the time to reach a MAC value for two fifferent anaesthetic machines, Flow-i versus Aisys looking at the time to reach 1 MAC desflurane

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

ASA 1-2 patient 18 - 65 years scheduled for elective surgery

Exclusion criteria

ASA \> 2 heart failure COPD

Design outcomes

Primary

Measure	Time frame	Description
Time to reach 1.5 MAC (minimal alveolar concentration) Et	1 hour	The time needed, seconds, to increase the end tidal desflurane concentration during wash-in from a 1 MAC to a 1.5 MAC with a constant fresh gas flow of 1 L/min and the vaporiser set a 3 MAC ( minimal alveolar concentration) (18%) will be compared between the two study groups

Secondary

Measure	Time frame	Description
amount of inhaled agent consumed ml/min	5 hours	The vaporiser will be weighed before and after each case and the amount of vapor, desflurane, consumed during the anaesthesia will be calculated Gr/min.
Postoperative Quality of Recovery	72 hours	Quality of recovery will be followed during the first 72 hours after anaesthesia

Other

Measure	Time frame	Description
Adequate anaesthesia	5 hours	Patients will be asked after end of anaesthesia if they have had any recall of intraoperative events

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026