Description of Insulin Resistance in Patients With Chronic Heart Failure

Description of Insulin Resistance and Explanatory Variables in Patients With Chronic Heart Failure

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02013739

Enrollment

Registered

2013-12-17

Start date

2011-05-31

Completion date

2013-12-31

Last updated

2013-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Heart Failure

Brief summary

The purpose of this study is to describe insulin resistance in a general chronic heart failure population, in combination with muscle strength, body composition and cardiac function. It is assumed that insulin resistance is increased in CHF patient, and that this is related to decreased muscle strength and decreased lean tissue mass.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* diagnosis of chronic heart failure for at least 6 months, * clinically stable (not hospitalized) for more than 3 months prior to the onset of the study,

Exclusion criteria

* glucose lowering medical therapy

Design outcomes

Primary

Measure	Time frame	Description
Glucose tolerance	day1	glucose and insulin concentration measurements in blood during oral glucose tolerance test

Secondary

Measure	Time frame
HbA1c, blood lipids, BNP	day 1
Muscle strength: maximal strength tested on a isokinetic dynamometer	Day 1
Body composition: dual energy x-ray absorptiometry	Day 1
cardiac function: echocardiography, retrospective from hospital files	retrospective
Health-related quality of life: MLHFQ and Eq5d	Day 1

Countries

Belgium

Outcome results