Cryopreservation of Embryos
Conditions
Brief summary
Randomized controlled trial (RCT) testing the hypothesis that vitrification is superior to slow freezing.
Interventions
OTHERcryopreservation technique
Sponsors
Sophie Debrock
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Patients (with female age \< 40 years) * Patients undergoing a 1st oocyte retrieval for an IVF/Intracytoplasmatic Sperm Injection (ICSI) treatment * Patients planned for an embryo transfer on day 3. * Patients with supernumerary embryos of sufficient quality for freezing/vitrifying on day 3. * Fresh personal (own oocytes) * One inclusion in the study per patient.
Exclusion criteria
* Patients undergoing a 2nd or higher ranked oocyte retrieval after a fresh cycle with failed pregnancy. * Female age ≥ 40 year * Patients with Preimplantation Genetic Diagnosis (PGD) * Patients with donor oocytes * Patients with positive serology whose embryos may not be frozen. * Patients planned for a transfer on day 2 or day 5. * Patients receiving assisted hatching in the embryo transfer in the frozen cycles. * Patients who have been included in the study before.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Life birth rate per embryo thawed | 3 years |
Secondary
| Measure | Time frame |
|---|---|
| live birth rate per embryo transferred | 3 |
| survival rate | 3 year |
| implantation rate per embryo transferred | 3 years |
| implantation rate per embryo thawed | 3 years |
| abortion rate | 3 years |
Countries
Belgium
Outcome results
None listed