Colorectal Surgery
Conditions
Keywords
analgesia; colorectal surgery; immunity; local anesthetics; opioids
Brief summary
The purpose of this study is to compare postoperative immune function (e.g. NK cell activity) of fentanyl-based analgesic regimen versus local anesthetic wound infiltration-based anlagesic regimen after laparoscopic colorectal surgery
Interventions
DRUGfentanyl-based analgesia
fentanyl based patient-controlled analgesia + additional pethidine for postoperative 48 hour
DRUGlocal anesthetic wound infiltration-based anlagesia
continuous wound inflitration with ropivacaine + tramadol patient-controlled analgesia + additional ketorolac or propacetamol for postoperative 48 hour
Sponsors
Severance Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* ASA class I-III * 20-80 years old * elective laparoscopic colorectal surgery for cancer
Exclusion criteria
* drug allergy * significant renal or hepatic impairment * sign of infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| NK cell activity | 48 hours | NK cell activity : preoperation, POD 1, POD 2 |
| IL-2 | 48 hours | IL-2 level : preoperation, POD 1, POD 2 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Complication and recurrence | 1 year | Postoperative complication, recurrence |
Other
| Measure | Time frame | Description |
|---|---|---|
| Inflammatory responses | 48 hours | White blood cell, neutrophil, C-reactive protein (CRP) : preoperation, POD 1, POD 2 |
Countries
South Korea
Outcome results
None listed