Anesthesia
Conditions
Brief summary
The objective is to evaluate the sparing effect of ketamine on the dose of propofol.
Interventions
DRUGKetamine
DRUGPlacebo
Sponsors
Hopital Foch
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients with an American Society of Anesthesiology score 1, 2 or 3 * scheduled for a surgical procedure lasting more than 2 hours under general anesthesia
Exclusion criteria
* pregnancy * chronic pain * simultaneous general and loco-regional anesthesia * contra-indication to to nonsteroidal anti-inflammatory drug * contra-indication to Ketamine * contra-indication to propofol, to remifentanil, to morphine * history of central nervous system disease * patients receiving a psychotropic treatment * patients with a pace-maker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| administered dose of propofol during maintenance of anesthesia | day 1 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| administered dose of propofol during induction of anesthesia | day 1 | — |
| administered doses of remifentanil during induction and maintenance of anesthesia | day 1 | — |
| delay (measured as minutes) between the end of propofol and remifentanil administration and the recovery from anesthesia | day 1 | — |
| hemodynamic abnormalities requiring treatment | day 1 | — |
| bispectral index measurement | 1 day | bispectral index modification due to ketamine infusion before induction of anesthesia |
| postoperative morphine requirement | day 1 | — |
| incidence of postoperative nausea and vomiting | day 1 | — |
| White and Song score | day 1 | — |
| % of patients with an explicit memorisation of the intraoperative period | second postoperative day | — |
| % of time with a bispectral index between 40 and 60 | day 1 | — |
Countries
France
Outcome results
None listed