Dysplasia in Longstanding Achalasia, Relation Between Food Stasis and Dysplasia
Conditions
Brief summary
Patient with achalasia have a 10-50 fold increased risk to develop esophageal squamous cell carcinoma (ESCC). Early diagnosis of ESCC is essential, and detection of an earlier dysplastic stage is preferred. Endoscopic detection is however difficult and often delayed. Chromoendoscopy with Lugol dye increases detection rates dysplasia and ESCC to 91-100%. The aim of this study was therefore to evaluate a screening program using chromoendoscopy with Lugol to detect dysplasia in patients with idiopathic achalasia. A second objective is to study the relationship between foodstasis and the development op dysplasia
Interventions
OTHERchromoendoscopy
chromoendoscopy (lugol stain and virtual chromoendoscopy)
Sponsors
KU Leuven
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* longstanding achalasia (\> 15y) * \> 18y old * informed consent
Exclusion criteria
* allergy to iodine * esophageal carcinoma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of dysplasia in patients with longstanding achalasia | 1 year |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| additive value of chromoendoscopy in comparison with lugol stain | 1 year | — |
| relationship between food stasis and dysplasia | 1 year | * relationship between elevated LES pressure and dysplasia * relationship between stasis on EndoFLIP and dysplasia * relationship between stasis on timed barium esophagogram and dysplasia |
Countries
Belgium
Outcome results
None listed