Patent Ductus Arterioses
Conditions
Keywords
patent ductus arterioses, ductal closure, thrombocyte
Brief summary
Although thrombocytopenia has been reported as a risk factor for patent ductus arterioses, there is lack of data on the function of platelets in ductal closure. Information on functions of platelets in ductal closure may change the known model for ductus arterioses and may affect the treatment modalities.
Detailed description
Patent ductus arterioses is a common problem which involves both pulmonary and cardiac outcomes in preterm infants. Although thrombocytopenia has been reported as a risk factor for patent ductus arterioses, there is lack of data on the function of platelets in ductal closure. The investigators aim to investigate the relation between thrombocytopenia and platelet functions in pathogenesis of spontaneous ductal closure. The investigators hypothesize that Information on functions of platelets in ductal closure may change the known model for ductus arterioses and may affect the treatment modalities.
Interventions
None listed
Sponsors
Ankara University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
2 Days to 7 Days
Healthy volunteers
Yes
Inclusion criteria
* gestational age lower than 30 weeks and birth weight lower than 1500 g * obtained informed consent
Exclusion criteria
* any received medical treatment in first 2 days of life * death in first 2 days * patients who received any thrombocyte or fresh frozen plasma suspensions * any known genetic thrombocyte disorder in the family
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| spontaneous ductal closure | 8 weeks | ductal closure confirmed by echocardiography on postnatal 2-3 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| need for treatment | 8 weeks | any need for medical treatment (ibuprofen or paracetamol) or surgical treatment |
Countries
Turkey (Türkiye)
Outcome results
None listed