Psychotic Disorders
Conditions
Keywords
Psychosis, Adverse effects, Symptom Severity, Magnetic Resonance Imaging
Brief summary
The purpose of this study is to compare abdominal weight gain and fat distribution to changes in brain morphology in people taking antipsychotic medications.
Detailed description
Abdominal weight gain is a significant side effect of antipsychotic medications. It has even been suggested to be part of the pathology of severe mental illnesses. Studies have shown that in persons with bipolar disorder, increased body mass index (BMI) is associated with irregular changes in the brain. This association has not been tested in persons with psychosis. In this study, we will be measuring abdominal fat distribution as measured by MRI to see if this is associated with abnormal brain morphology.
Interventions
None listed
Sponsors
University of British Columbia
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
12 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Must be admitted to the BC (British Columbia) Psychosis Program at UBC (University of British Columbia) Hospital * Must have clinically diagnosed psychosis (e.g. schizophrenia) * Must be fluent in English * Must not be contraindicated for MRI (i.e., must not be claustrophobic, have metal in the body, be pregnant, have BMI greater than or equal to 40, etc.)
Exclusion criteria
• None, other than those listed above
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Abdominal distribution of visceral fat versus subcutaneous fat | Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge | Change over time in amounts of visceral and subcutaneous fat as measured by automated segmentation of a magnetic resonance image (MRI) |
| Changes in total brain volume | Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge | Change over time in total brain volume as measured by automated segmentation of a magnetic resonance image (MRI). |
| Changes in grey matter volume in the brain | Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge | Change over time in amounts of brain grey matter as measured by automated segmentation of a magnetic resonance image (MRI). |
| Changes in white matter volume in the brain | Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge | Change over time in amounts of brain white matter as measured by automated segmentation of a magnetic resonance image (MRI). |
| Changes in the volume of brain structures | Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge | Change over time in the volume of brain structures as measured by automated segmentation of a magnetic resonance image (MRI). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparing changes in abdominal fat distribution/accumulation to psychosis symptom severity | Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge | To determine if an association exists between abdominal fat accumulation/distribution and psychosis symptom severity, as measured by the amounts of visceral and subcutaneous fat by automated segmentation of a magnetic resonance image (MRI) and standardized symptom rating scales, cognitive tests, and other neuropsychological examinations, respectively. |
Countries
Canada
Contacts
Primary ContactHeidi N Boyda, Ph.D.
Backup ContactDelrae Fawcett, M.Sc.
Outcome results
None listed