Obesity, Type 2 Diabetes
Conditions
Keywords
Insulin resistance, Inflammation, Hypoxia
Brief summary
Obesity is an epidemic in Western society and is the biggest risk factor for insulin resistance and type 2 diabetes. The investigators have recently shown that exposure to hyperbaric oxygen (HBO) leads to an increase insulin sensitivity in males ubjects and that this improvement can be measured in all men, not just those with diabetes. The aim of this study is to investigate the time course of this effect and explore the mechanisms involved. The investigators suspect that insulin sensitivity as measured by hyperinsulinaemic-euglycaemic clamp will be increased within the time-frame of one 2-hour hyperbaric oxygen exposure, and that the improvement will be measurable in females as well as males.
Interventions
PROCEDUREHyperbaric Oxygen Therapy
Participants will undergo 2 treatments of hyperbaric oxygen. Each treatment consists of 90 minutes compression at 2 atmospheres of pressure, with 30 minutes decompression back to 1 atmosphere. During this time, patients will be treated with 100% oxygen delivered via a hood system.
Sponsors
University of Adelaide
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Overweight to obese (BMI 25-35 kg/m2) * Age \>18 years (no specific upper age limit) * Fit to enter hyperbaric chamber as assessed by hyperbaric physician.
Exclusion criteria
* Personal history of Diabetes * Personal history of major psychiatric disorders * UIse of prescribed or non-prescribed medications which may affect glucose homeostasis (e.g. steroids), * Uncontrolled asthma, * Current fever or upper respiratory infections * Individuals who regularly perform high intensity exercise (\>2 week), * Pregnancy, lactation and women who are planning to become pregnant * Current intake of \>140g alcohol/week, * Current smokers of cigarettes/cigars/marijuana, * Current inatke of any illicit substance, * Claustrophobia * has donated blood within past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin sensitivity | 2 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hypoxia and inflammatory markers | 2 hours | Using immuno-histo chemistry (IHC), quantitative plymerase chain reaction (qPCR), Western blot |
Countries
Australia
Outcome results
None listed