Heart Failure
Conditions
Keywords
Rehabilitation, Exercise Training, Interval training
Brief summary
The aim of the present study is to evaluate differential lactate removal kinetics in heart failure patients that are trained according to 2 different exercise protocols: (A) High intensity intervals training (HIT); (B) Continuous moderate aerobic training (MAT)
Detailed description
Introduction: Congestive heart failure (CHF) patients suffer from early fatigue and functional aerobic impairment. Their reduced cardiac output and O2 delivery to the peripheral muscles shifts those patients consistent anaerobic metabolism, thus, CHF patients rely on anaerobic metabolism even in everyday life activity. This metabolism leads to a shift of muscles fiber types from mainly slow twitch, oxidative type I fibers to fast twitch, glycolytic type IIb fibers. Monocarboxylate proteins MCT1 and MCT4 transport lactate crosses the membrane. MCT1 is responsible for the lactate uptake and MCT4 is responsible for efflux of excess lactate. Exercise training is known to improve the quality of life in CHF. We hypothesized that exercise training might change MCT1 and 4 expression and distribution. Accordingly, these changes may also affect lactate clearance during recovery, which may contribute to the beneficial effect of exercise training in CHF patients. Methods: New-York Heart association (NYHA) class II-III CHF patients will be assigned to the experiment. At baseline and upon training conclusion they will undergo the same tests battery. The test battery includes heart rate, blood pressure measurements, echocardiographic evaluation. All participants will fill out Minnesota living with heart failure questionnaire. Subsequently, after their basal blood lactate will be assessed they will undergo measurement which will be followed by lactate clearance-rate evaluation. Randomly each patient will then be assigned to one of two experimental training groups: (A) High intensity intervals training (HIT); (B) Continuous moderate aerobic training (MAT). Each volunteer will be trained twice a week for 12 weeks, according to his/hers assigned training protocol and in accordance to exercise training guidelines.
Interventions
OTHERContinues aerobic training
Sponsors
Dr. Robert Klempfner Heart Rehabilitation Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Stable heart failure patients referred to exercise training in a tertiary care cardiac rehabilitation institute * Age \> 21
Exclusion criteria
* Severe symptomatic heart failure * Severe orthopedic limitations * Unstable arrythmia * Cognitive decline or substance abuse * Unable to comply with exercise protocol * Significant pulmonary disease * NYHA 4 heart failure class
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lactate clearance kinetics | Baseline and following 12 weeks of training | Change from baseline of lactate clearance kinetics followoing a 12 weeks exercise program based on two different training protocol (continues and interval training) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Peak VO2 change | Pre- and post 12 week exercise program | Change from baseline of the peak VO2 following the 12 weeks exercise program |
Other
| Measure | Time frame |
|---|---|
| Quality of life questioner (MLWHF) | Pre training and 12 weeks later post exercise training period |
Countries
Israel
Outcome results
None listed