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A Comparison of Propofol Based Total Intravenous Anesthesia and Sevoflurane Based Balanced Anesthesia on Renal Protection During Lung Transplantation Under Extracorporeal Membrane Oxygenation - A Prospective, Randomized Trial

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02009280
Enrollment
60
Registered
2013-12-11
Start date
2013-11-30
Completion date
2016-07-31
Last updated
2016-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients Undergoing Lung Transplantation Under Extracorporeal Membrane Oxygenation

Keywords

Propofol, Lung transplantation, Extracorporeal membrane oxygenation, Acute kidney injury

Brief summary

The aim of this study is to investigate whether propofol based total intravenous anesthesia reduces incidence of acute kidney injury following the lung transplantation under extracorporeal membrane oxygenation

Interventions

DRUGAdministration of anesthesia: Propofol

Maintenance of anesthesia with the propofol

DRUGAdministration of anesthesia: Sevoflurane

Maintenance of anesthesia with the sevoflurane

Sponsors

Yonsei University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Sixty adults undergoing lung transplantation under extracorporeal membrane oxygenation

Exclusion criteria

* Patient having propofol allergy, BMI \> 30 kg/m2

Design outcomes

Primary

MeasureTime frameDescription
Comparison of the incidence of acute kidney injury between the lung transplantation recipients under propofol based anesthesia and inhalation based anesthesiaPostoperative 48 hoursDevelopement of the acute kidney injury is determined by Plasma neutrophil gelatinase-associated lipocalin (NGAL), Cystatin C, and Creatinine

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026