Hyperuricemia, Insulin Resistance, Prediabetes
Conditions
Brief summary
Several studies showed that hyperuricemia is an independent risk factor for development of diabetes mellitus. However none of the previous studies have investigated the effect of lowering serum uric acid levels on insulin resistance of which is also named as prediabetes. With this background in mind, we aimed to test the effect of lowering serum uric acid level with allopurinol on insulin resistance.
Interventions
DRUGallopurinol 300 mg./day
OTHERNo intervention
DRUGNormouricemic
Sponsors
Istanbul Medeniyet University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Age ≥ 30 * Serum uric acid level ≥7mg/dL * Glomerular filtration rate ≥60 ml/min
Exclusion criteria
* presence of Diabetes Mellitus * history of gout * history of allopurinol use * body mass index ≥35 kg/m2 * proteinuria ≥ 1gr/ day * presence of autoimmune disease * rheumatology associated disease * presence of hypothyroidism or hyperthyroidism * presence of diseases which may cause chronic inflammation or microalbuminuria (e.g. malignancy, chronic liver disease, hypertension, chronic lung disease)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in insulin resistance (HOMA-IR) | baseline and 3 months |
Countries
Turkey (Türkiye)
Contacts
Primary ContactMehmet Kanbay, Associate Professor
Outcome results
None listed