Atrial Fibrillation and Neuropathic Pain After Thoracotomy and Continuous Application of Magnesium Sulphate.

Effects of Prophylactic Administration of Magnesium Sulfate on the Incidence of Atrial Fibrillation and Chronic Neuropathic Pain After Thoracotomy for Lung Resection.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02008747

Enrollment

100

Registered

2013-12-11

Start date

2011-01-31

Completion date

2012-05-31

Last updated

2013-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation, Neuropathic Pain

Keywords

Atrial fibrillation, Neuropathic pain, Posterolateral thoracotomy, Lung resection

Brief summary

Atrial fibrillation and chronic neuropathic pain are adverse events occurring after posterolateral thoracotomy for lung resection. The continuous application of magnesium sulphate may have a prophylactic effect. The investigators record the incidence of atrial fibrillation during a seven day period after thoracotomy as well as the incidence of chronic neuropathic pain during a three months period, comparing one group with a continuous application of magnesium sulphate against one group without magnesium sulphate.

Interventions

DRUGMagnesium sulphate

Continuous application of magnesium sulphate applied 40 mg/kg ideal body weight by bolus before the operation started, followed by a continuous infusion of 10 mg/kg ideal body weight/h for 24 hours

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 18 years or older * posterolateral thoracotomy for lung parenchyma resection * informed consent

Exclusion criteria

* hypersensitivity for magnesium sulphate * pre-existing atrial fibrillation * participation in another trial * pregnancy or breastfeeding

Design outcomes

Primary

Measure	Time frame	Description
Incidence of atrial fibrillation	Up to 168 hours after operation	The incidence of atrial fibrillation was recorded using a 12 lead ECG for a period of 7 days after operation

Secondary

Measure	Time frame	Description
Chronic neuropathic pain	Three months	The incidence of neuropathic pain was recorded using the LANSS Score during a period of three months after posterolateral thoracotomy for lung resection.

Other

Measure	Time frame	Description
Hypotonia	24 hours perioperative	The incidence of hypotonia during the time of continuous magnesium sulphate application was recorded.

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026