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Bronchoreversibility and Radiologic Morphology of Emphysema

Response to Bronchodilation With Tiotropium Plus Salbutamol Correlates With Radiologic Morphology of the Lung in COPD of the Emphysematous Phenotype

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02008162
Enrollment
60
Registered
2013-12-11
Start date
2009-11-30
Completion date
Unknown
Last updated
2013-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emphysema, COPD

Keywords

Emphysema, COPD, bronchoreversibility, ventilatory obstruction, lung volume reduction surgery, LVRS

Brief summary

To assess response to bronchodilation with tiotropium plus salbutamol in patients with severe emphysema and analyze relationships between bronchoreversibility response and semiquantitative computed-tomography based emphysema severity measures.

Interventions

DRUGBronchodilators

Administration of both albuterol and tiotropium bromide after a 48h period of washout from all bronchodilators, followed by spirometry and plethysmography

Sponsors

University of Rome Tor Vergata
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

* Radiologic evidence of severe heterogeneous emphysema * GOLD COPD class III-IV * No other significant pulmonary comorbidity * Quit smoking since at least 4 months

Design outcomes

Primary

MeasureTime frameDescription
post-bronchodilator FEV1 change1 hAssessed by spirometry carried out before and after administration of bronchodilators
post-bronchodilator change in FVC1hAssessed by spirometry carried out before and after administration of bronchodilators

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026