Healthy
Conditions
Brief summary
The purpose of is to determine the preventive effects of Chinese herb supplement with panax ginseng and salvia miltiorrhiza prior to eccentric resistance exercise on arterial stiffness and vascular reactivity by using a double-blind randomized control design and to examine the effects of a 12-week progressive eccentric resistance exercise training on arterial elasticity and vascular reactivity, and whether a long-term supplementation would ameliorate arterial stiffening effects elicited by exercise-induced inflammation and improve endothelial function.
Interventions
BEHAVIORALEccentric exercise training
12 weeks of lower leg eccentric training
Sponsors
National Taiwan University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
-Healthy sedentary adults
Exclusion criteria
* obesity (BMI \>30 kg/m2) * smoking within past six months * hypertension (high blood pressure \>140/90 mmHg) * personal history of diabetes (fasting blood glucose \>126 mg/dL), heart disease, or other cardiovascular problems * orthopedic injury that may prevent him or her from completing the exercise * the use of over-the-counter supplements or vitamins
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pulse Wave Velocity | Before eccentric exercise and training | PWV will be measured before, 6th week, 12th week of eccentric exercise training. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure | Before intervention | Morning blood pressure will be measured before, during, and after 12 week of dietary and eccentric exercise intervention. |
Countries
Taiwan
Contacts
Primary ContactHsin-Fu Lin, Ph.D.
Outcome results
None listed