Infection During Renal Replacement Therapy
Conditions
Keywords
HD, CVVH, renal replacement therapy, ceftaroline, pharmacokinetics
Brief summary
The study will be conducted to investigate the pharmacokinetics of ceftaroline during continuous and intermittent renal replacement therapy.
Interventions
OTHERCeftaroline in CRRT
Plasma levels of ceftaroline will be measured in patients receiving CRRT
OTHERCeftaroline in IRRT
Ceftaroline plasma levels will be measured in patients receiving intermittent renal replacement therapy
Sponsors
Medical University of Vienna
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \>18 years, able to give written informed consent * Suspected or proven bacterial infection requiring parenteral antibiotic therapy. * Renal replacement therapy (continuous or intermittent)
Exclusion criteria
* Known hypersensitivity to ceftaroline or other cephalosporins, or severe hypersensitivity (anaphylactic reaction) to beta-lactam antibacterial agents. * An expected survival of less than two days. * Known pregnancy * Coadministration of valproic acid or probenecid, which cannot be discontinued for the duration of the study * Ceftaroline as monotherapy for resistent species or fungal infections. * Other reasons oposing the study participation on the discretion of the investigators
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Influence of renal replacement therapy on the area under concentration curve of ceftaroline plasma concentration levels. | day 15 | Pharmacokinetic samples are drawn on multiple timepoints from each patient during his participation. |
Countries
Austria
Contacts
Primary ContactFlorian Thalhammer, Prof. MD
Outcome results
None listed