Oxidative Stress
Conditions
Keywords
Meal, Postprandial oxidative stress
Brief summary
This one-year randomized crossover study is proposed to compare the changes of postprandial oxidative stress (POS) after consumption of meals from different cultures in healthy Chinese adults, using a 'real-life, cultural meal' approach. It is hypothesized that the changes of POS differ with meals from different cultures. Four cultural meals are chosen, namely Southern Chinese, Northern Chinese, American, and South Indian, based on the known prevalence of chronic diseases between Caucasians, Chinese and Indians, and within the Southern and Northern Chinese population.
Interventions
OTHERSouthern Chinese meal
White rice (1 bowl), stir fried choi sum (0.5 bowl) and stir fried lean pork (0.5 bowl) cooked with maize oil
OTHERNorthern Chinese meal
Noodles (1 bowl) and shredded pork with sweet bean sauce (0.5 bowl) cooked with blend oil
OTHERAmerican meal
Hamburger with cheese (1 piece), French fries (117 g) cooked with canola blend oil and Coca-cola classic (21 fluid ounces)
OTHERSouth Indian meal
Basmati rice (1 bowl), chicken curry dish (0.5 bowl), dry vegetable dish (i.e. green beans mixed with herbs) (0.5 bowl), yogurt made with milk powder mainly (0.5 bowl), pickle made with lemon, salt, chilli powder, Asafoetida and vegetable based oil (1 tablespoon)
Sponsors
Chinese University of Hong Kong
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Apparently healthy male or female of Chinese ethnicity with BMI less than 25 kg/m2 * Aged from 18 to 45 years for female to avoid menopausal effect, and 18 to 50 years for male (inclusive) * Normal glucose tolerance as assessed by fasting HbA1c of \<6% at the screening * Willing to give consent and follow the study procedures
Exclusion criteria
* Lifestyle factors that affect POS as shown by the literature including * Current smoker * Physically active as defined by three days or more of 30 minutes \[accumulated over the course of a day\] moderate to vigorous activity weekly in the past three months. Vigorous physical activity is described as causing heavy sweating or a large increase in breathing or heart rate, and moderate as causing light sweating or a slight to moderate increase in breathing or heart rate. * Regular or current use of vitamin or antioxidant supplements * Pregnant or lactating * Concurrent participation in any clinical trial or dietary intervention program * Adherence to a special diet, allergies or aversions to foods on the study meals * Use of medications that could affect study outcomes * With diabetes, hypertension, renal, liver or thyroid dysfunction, any other indication of a major medical or psychological illness, as judged by the investigators as ineligible to participate the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of plasma allantoin from 0 (pre-meal) to 6 hours post-meal | pre-meal (0 hour), 2, 4, 6 hours post-meal |
Secondary
| Measure | Time frame |
|---|---|
| Change of urine F2-isoprostanes from 0 (pre-meal) to 6 hours post-meal | pre-meal (0 hour), 2, 4, 6 hours post-meal |
Countries
China
Outcome results
None listed