Central Nervous System Diseases
Conditions
Brief summary
The investigators hypothesize that ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.
Detailed description
Excitatory (\>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal gyrus.
Interventions
Using high-sensitivity infrared to detect the active brain areas
DEVICErTMS
To modulate brain cortex
Sponsors
Taipei Veterans General Hospital, Taiwan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Ischemic or hemorrhagic cerebrovascular lesion, 2. Parkinson's disease
Exclusion criteria
* Seizure * With metal implantation * Dementia or severe cognitive impairment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Repeatable Battery for the Assessment of Neuropsychological Status | Up to 12 weeks | Test cognition including memory, attention, language... |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of Montreal Cognitive Assessment | Up to 12 weeks | Test cognition including memory, attention, and language. |
| Change of Fugl-Meyer Assessment , Wolf Motor Function Test | Up to 12 weeks | Test upper limb motor function. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change of hand grip, pinch power | Up to 12 weeks | Test hand strength. |
Countries
Taiwan
Contacts
Primary ContactPo-Yi Tsai, MD
Backup ContactChih-Jou Lai, MD
Outcome results
None listed