Postprandial Glycemia
Conditions
Brief summary
In this study, the postprandial glycemia and insulinemia caused by boiled potato with blue-fleshed or yellow-fleshed tubers, or a gel prepared with bilberries and potato starch, is studied in healthy males. Additionally, the appearance and metabolism of the flavonoids and their metabolites is studied in plasma and urine.
Interventions
OTHERDietary intervention
Sponsors
University of Turku
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-45 * Male * No regular medication * No participation in a drug trial or blood donation within 2 months * Non-smoker * Signs informed consent * Body mass index 18.5-27 kg/m2 * Fasting plasma cholesterol \< 5.5 mmol/l * Fasting plasma triacylglycerols \< 2.6 mmol/l * Fasting plasma glucose 4-6 mmol/l * blood pressure \<140/80 mmHg * hemoglobin\>130 g/l * Fasting plasma alanine amino transferase (ALAT) \<60 U/l (normal liver function) * Fasting plasma thyroid-stimulating hormone (TSH) 0.4 - 4.5 mU/l (normal thyroid function) * Fasting plasma creatinine \<118 µmol/l (normal kidney function)
Exclusion criteria
* Regular smoking * Alcohol abuse * Regular medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma glucose concentration | 20min, 40min, 60min, 90min, 120min, 180min, 240min |
| Plasma insulin concentration | 20min, 40min, 60min, 90min, 120min, 180min, 240min |
Secondary
| Measure | Time frame |
|---|---|
| Concentrations and quality of flavonoid color compounds or their metabolites in plasma and urine (HPLC-measurement) | 20min, 40min, 60min, 90min, 120min, 180min, 240min |
| Concentrations and quality of flavonoid color compounds or their metabolites in plasma and urine (NMR-measurement) | 20min, 40min, 60min, 90min, 120min, 180min, 240min |
Countries
Finland
Outcome results
None listed