Prelingual Deafness, Retention Disorders, Cognitive
Conditions
Keywords
Prelingual Deafness, Retention Disorders, Cognitive, Sign language, Mini-Mental State
Brief summary
In France the prevalence of pre-lingual deafness is between 1 and 1.4 per 1000 habitants, and according to very conservative estimates, about 44 000 deaf persons use the sign language. Additionally, the prevalence of dementia in France is close to 1% (850 000 dements for a total population of 65 millions). The prevalence of dementia in pre-lingual deaf adults has also been described and is between 1 and 1.4 /100 000 habitants. The Mini Mental State Examination (MMSE) of Folstein is a test recommended to perform the cognitive evaluation for the detection of mental disorders including dementia, and a consensual French version exists prepared by GRECO (Group of Research and Cognitive Assessments). However, to date, there are no simple, rapid and validated screening tests to study cognitive disorders in deaf persons who use the sign language. The only tests available allow a late diagnosis avoiding an optimal treatment of the patients.
Detailed description
The objective of this study is to assess the intrinsic quality of the tool MMS-LS, a mini-mental state examination that has been adapted to the sign language in order to monitor cognitive disorders in deaf people who speak sign language.
Interventions
BEHAVIORALapplication of the mini-mental state test
Sponsors
Lille Catholic University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults\> 18 years * Pre-lingual deafness * Use of French sign language
Exclusion criteria
* Refusal to sign the consent * Severe visual impairment with lower acuity (less than 0.5) * Severe motor difficulties impeding the practice of sign language
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of internal consistency of MMS-LS test for the diagnosis of cognitive impairment among deaf patients by a correlation analysis followed by Cronbach's alpha test | At baseline, 1 year and 2 years follow-up visits |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Description of MMS-LS test results | Baseline | Explanatory Factors are: age, education level, characteristics of the sign language(fluency level, learning age, usage frequency, usage by other family members) |
| Diagnostic performance and predictive values of MMS-LS test for acquired dementia. | Baseline, 1 year and 2 years follow-up visits | Sensitivity, specificity, positive and negative predictive values. |
| Correlation between MMS-LS score and CDR level | Baseline, 1 year and 2 years follow-up visits | We also check that patients having a suspicious CDR (0.5) have a superior MMS-LS score compared to patients having a CDR ≥ 1. |
| Diagnostic performance and predictive values of MMS-LS test for suspected dementia. | Baseline, 1 year and 2 years follow-up visits | Sensitivity, specificity, positive and negative predictive values |
Countries
France
Outcome results
None listed