Neutrophil Extracellular Traps and Sickle Cell Disease

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02004808

Enrollment

Registered

2013-12-09

Start date

2014-02-28

Completion date

2019-12-31

Last updated

2013-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sickle Cell Anemia

Brief summary

NETs formation in vaso-occlusive events in sickle cell disease and the role of hydroxyurea treatment.The study hypothesis is that NETs formation by neutrophils has a role in the induction of vaso occlusive disease in blood vessels. It is possible that high leukocyte count in children with sickle cell anemia is a bad prognostic sign due to NETs formation supporting occlusion of peripheral and central blood vessels.Hydroxyurea treatment might prevent vaso occlusive syndrome not only by increasing HbF but also by decreasing neutrophil count and inhibiting NETs formation.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Months to 18 Years

Healthy volunteers

Inclusion criteria

* children who suffer from sickle cell disease and/or children with sickle cell disease treated with hydroxyurea

Exclusion criteria

* none

Design outcomes

Primary

Measure	Time frame
measurements of neutrophil function	at first admition (day 1)

Secondary

Measure	Time frame
measurements of neutrophil function	at sickle cell crisis while hospitalized

Other

Measure	Time frame
measurements of neutrophil function	before and during treatment with hydroxyurea

Contacts

Primary ContactRonit Elhasid, MD

ronite@tasmc.health.gov.il972524266464

Outcome results