Assessment Study of the Effect of NMBA on Bowel Peristalsis

Effect of an Induction Dose of Non Depolarizing Neuro Muscular Blocking Agents (NMBA) on Ultrasound Bowel Peristalsis.

Status

Terminated

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02004015

Acronym

CURARES

Enrollment

Registered

2013-12-06

Start date

2013-11-30

Completion date

Unknown

Last updated

2017-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Physiopathology

Keywords

Analytical, Diagnostic, Anesthesia, Analgesia

Brief summary

Phase III prospective randomised study : curare vs placebo, comparing bowel peristalsis (abdominal echography) in the first minutes of after general anesthesia induction. Primary End Point: proportion of patients with a score of motion = 0

Detailed description

Primary End Point Proportion of patients with a score of motion = 0 Secondary End Point Time at which thumb adductor twitch measurement disappears (3rd consecutive measure with a twitch at 0) Mean minimal twitch measurement for those patients in who twitch measurement does not disappear Concordance study between twitch measurement and bowel peristalsis XML File Identifier: 1vUwHz2uUXeSc7soLu1cQwRAfcM= Page 15/24 ultrasound score.

Interventions

DRUGinjection of placebo

0.5 mg/kg milligram(s)/kilogram

DRUGinjection of NMBA

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* elective surgery * scheduled oro tracheal intubation

Exclusion criteria

Counter indication to NMBA: * predicted difficult airway * surgical counter indication: facial or laryngeal nerve function monitoring * allergy to muscle relaxants neuro muscular disease Possible alteration of sensitivity to muscle relaxants due to ongoing medication: ex Valproate or aminoglycoside antibiotics. Predictable alteration of bowel movements or difficult abdominal ultrasound: * scheduled abdominal surgery * abdominal surgery in last month * obesity: body mass index over 30 Full stomach or pregnancy requiring suxamethonium for intubation

Design outcomes

Primary

Measure	Time frame	Description
Proportion of patients with a score of motion = 0	10 minutes after NMBA or placebo injection	Proportion of patients with a score of motion = 0

Secondary

Measure	Time frame	Description
Time at which thumb adductor twitch measurement disappears	1 month after injection	Time at which thumb adductor twitch measurement disappears (3rd consecutive measure with a twitch at 0). Mean minimal twitch measurement for those patients in who twitch measurement does not disappear. Concordance study between twitch measurement and bowel peristalsis

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026