HIV Seropositivity
Conditions
Brief summary
HIV patients may suffer sooner from aging than average population, including brain aging. Our hypothesis is that if brain dysfunctions are explained by a quicker loss of neurons in HIV patients, this loss could be detected earlier by a thinning down of retinal nerve fiber layer (RNFL), compared to non HIV patients of the same age.
Detailed description
The investigators aim to compare the thickness of the RNFL and the thickness of the RCGs measured by spectral domain OCT between patients infected by HIV and patients of same age non infected by HIV.
Interventions
OTHERophthalmologic examination and MRI
thorough investigation of patients, not included in usual care.
Sponsors
Fondation Ophtalmologique Adolphe de Rothschild
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* HIV infection known since at least 10 years * viral load undetectable under ARV treatment since at least 5 years, whatever the type of ARV * lymphocytes CD4 \> 350, whatever the CD4 nadir * signed informed consent
Exclusion criteria
* History of ocular pathology, eye surgery, or intraocular injection * Familial History of glaucoma * ametropia (\>3 dioptres on the sphere and \>1,5 dioptres on the cylinder) * known neurological pathology, active or former * History of ethambutol or synthetic antimalarial drug consumption * History of chemotherapy * Active and regular use of drugs * non-weaned chronic alcoholism * contra indication to MRI * diabetes * cognitive disorders (MoCA\<26) * non covered by health insurance * patient under legal protection * pregnant or breast-feeding woman * Non inclusion criteria for control patients: known HIV infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| thickness of the RNFL and the RCGs measured by spectral domain OCT, between the two groups of patients | one day of examinations |
Countries
France
Outcome results
None listed