Effects of Viral Reactivation on Outcomes of Brain-injured Patients ( IBIS-VIRUS)

Conditions

Brain Injury

Keywords

Brain injury, virus, immunosuppression, mechanical ventilation

Brief summary

Morbidity and mortality of ICU patients is increased by the development of a immunosuppression systemic (IS). This IS develops in the early hours of hospitalization and is responsible for severe infections, including viral reactivations (Cytomegalovirus or Herpes Simplex Virus). Viral reactivation was associated with increased morbidity and mortality in intensive care units. In clinical practice, they are searched at the onset of organ failure or unexplained fever. The investigators wish to conduct this research in the stroke patients to assess the predictive power of these viral reactivations on the duration of mechanical ventilation.

Detailed description

PCR for herpes simplex virus in blood and in tracheal aspirate (Day-1, Day-7 and Day-15) - clinicians are blinded to the results PCR for Cytomegalovirus in blood and in tracheal aspirate (Day-1, Day-7 and Day-15) - clinicians are blinded to the results

Mélanie Petrier, Debajyoti Sinha, Florian P. Martin, Cécile Poulain, Delphine Flattres Duchaussoy et al. (17 authors)

Critical Care2026-03-12

10.1186/s13054-026-05946-6

Metagenome-assembled complete genome of <i>Bohxovirus</i>, a virulent bacteriophage involved in the prediction of hospital-acquired pneumonia in intubated critically ill patients.

Anani H, Destras G, Regue H, Bulteau S, Bressollette-Bodin C, Roquilly A, Josset L.

2025-10-29

10.1128/mra.00592-25

Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients.

Anani H, Destras G, Bulteau S, Castain L, Semanas Q, Burfin G, Petrier M, Martin FP, Poulain C, Dickson RP, Bressollette-Bodin C, Roquilly A, Josset L.

2025-09-05

10.1016/j.xcrm.2025.102289

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

No

Inclusion criteria

* Hospitalisation in intensive care unit * Acute brain injury (trauma, subarachnoid haemorrhage, stroke, infection) with Glasgow Coma Scale \<= 12 * Age between 18 and 75 years * Mechanical ventilation \> 24 hours

Exclusion criteria

* encephalopathy post anoxy * active cancer * Immunosuppresseur treatment * pregnancy * history of autoimmune disease

Design outcomes

Primary

Measure	Time frame
Ventilatory-free days at day 90	90 days

Secondary

Measure	Time frame
Bacterial hospital acquiered infection	28 days
organ failure	28 days
hospitalisation length of stay	28 days
Mortality	28 days and 90 days

Countries

France

Outcome results