General Anesthesia
Conditions
Keywords
Fluid Therapy, Head and Neck Neoplasms, Surgical Flaps
Brief summary
Investigators hypothesized that goal-directed fluid therapy using stroke volume variation will improve postoperative recovery in patients undergoing free flap reconstruction after head and neck cancer resection. Investigators will compare the effect of goal-directed fluid therapy using stroke volume variation on recovery in patients undergoing free flap reconstruction after head and neck cancer resection.
Interventions
PROCEDUREStandard fluid therapy
In Standard fluid therapy group, the administration of fluid will be guided to maintain mean blood pressure more than 65 mmHg, urine output more than 0.5 ml/kg/hr, and central venous pressure less than 14 mmHg.
PROCEDUREConservative fluid therapy
In Goal directed fluid therapy group, the administration of fluid will be guided by stroke volume variation. The anesthesiologist will infuse volulyte (Fresenius Kabi, Bad Homburg, Germany) 200 ml if stroke volume variation is over 12%. If cardiac index is below 2.5 l/min/m2 and stroke volume variation is below 12%, start dobutamine.
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* adult patients of age over 20 years scheduled for free flap reconstruction after head and neck cancer resection
Exclusion criteria
* valvular heart disease * congestive heart failure * liver failure * renal failure * pregnant woman * allergy to hydroxyethyl starch solutions * coagulation abnormalities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Length of hospital stay | 1 month after surgery |
Countries
South Korea
Outcome results
None listed