Superficial Esophageal Neoplasia
Conditions
Brief summary
This study aimed to compare Narrow Band Imaging (NBI) against Lugol chromoendoscopy for diagnosis of early esophageal cancers among high risk patients.
Detailed description
The investigators recruited consecutive patients with head and neck cancers, history of squamous esophageal cancers treated by chemoradiotherapy or endoscopic resection. Endoscopic surveillance first started with NBI for detection and characterization of early esophageal cancers through observation of abnormal intrapapillary capillary loops (IPCL). Superficial esophageal neoplasia were diagnosed by IPCL Type IV, V1,V2 and Vn. Lugol chromoendoscopy would be performed subsequently and suspicious neoplasia were classified as understain or unstain lesions. The diagnostic accuracy, sensitivity and specificity of NBI were compared to Lugol chromoendoscopy with histology serving as a gold standard.
Interventions
None listed
Sponsors
Chinese University of Hong Kong
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Patients with Head and Neck Cancer 2. Patients with esophageal cancer treated by chemoradiotherapy and in remission for 2 years 3. Patients with esophageal cancer treated by endoscopic resection 4. Age 18 to 80
Exclusion criteria
1. Allergy to Lugol iodine 2. Pregnancy 3. Previous esophagectomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy of superficial esophageal neoplasia | 1 month |
Outcome results
None listed