Caustic Esophageal Burns in Children and High Doses of Methylprednisolone

High Doses of Methylprednisolone in the Management of Caustic Esophageal Burns in Children

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02002078

Enrollment

Registered

2013-12-05

Start date

2007-02-28

Completion date

2008-12-31

Last updated

2013-12-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal Diseases

Keywords

caustic, corticosteroid therapy, stricture, children

Brief summary

Corrosive substance ingestion in childhood is a public health issue in developing countries and several management protocols were proposed to prevent esophageal strictures. The role of corticosteroids in preventing corrosive-induced strictures is controversial. The investigators' aim is to study the influence of high doses of corticosteroids to prevent esophageal strictures.

Interventions

DRUGmethylprednisolon

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

SINGLE (Caregiver)

Eligibility

Sex/Gender

ALL

Age

12 Months to 17 Years

Healthy volunteers

Inclusion criteria

-Corrosive substance ingested children with grade IIb esophageal burn

Exclusion criteria

* Caustic substance ingested chldren grade I, IIa and grade III esophageal burns * Caustic subtance ingested children with signs of perforation, mediastinitis, peritonitis, sespis * Caustic substance ingested children with any chronic disease

Design outcomes

Primary

Measure	Time frame	Description
Evaluation of stricture development in children with caustic esophageal burns after high doses of methylprednisolone	three years	stricture development was evaluated with endoscopic examination and upper gastrointestinal system series with barium swallow

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026