Inguinal Hernia, Nausea, Postoperative Pain, Pruritus, Vomiting
Conditions
Keywords
Spinal anaesthesia, morphine, postoperative analgesia, vomiting
Brief summary
The aim of this study was to compare the effects of two different doses of intrathecal morphine (0.1 mg and 0.4 mg) combined with 7.5 mg of heavy bupivacaine on postoperative block regression times, postoperative analgesia and the severity of side effects, for inguinal hernia repairs.
Detailed description
The purpose of this study was to compare spinal anesthesia with low dose heavy bupivacaine combined with 0.1 mg or 0.4 mg of morphine in inguinal hernia repair surgeries. Anesthesia onset time (sensory and motor blocks) as well as postoperative recovery (first mobilisation, first voiding) time were compared. Also the postoperative pain management and side effects (nausea, vomiting and pruritus) were assessed.
Interventions
DRUGintrathecal morphine 0.1 mg combined with intrathecal heavy bupivacaine 7.5 mg
DRUGintrathecal morphine 0.4 mg combined with intrathecal heavy bupivacaine 7.5 mg
DEVICEstandard monitoring with Datex Ohmeda anesthesia monitor, GE, Finland
electrocardiography, heart rate, pulse oximetry and noninvasive arterial blood pressure
DRUGintravenous cannulation and premedication
18-gauge intravenous cannula was inserted at the forearm opposite to the surgical side and routine iv premedication (midazolam 0.03 mg/kg) was given
Sponsors
Ankara University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anaesthesiology physical status I-II patients * aged 18-65 years * undergoing elective unilateral open inguinal hernia repair surgery
Exclusion criteria
* contraindications to spinal anesthesia * central or peripheral neuropathies * severe respiratory or cardiac diseases * chronic analgesic use * history of substance abuse * allergy to local anesthetics
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensory and motor block | The change in motor block and sensory block levels will be assessed after performing spinal block, every 5 minutes for 30 minutes and then at the end of the procedure. | Sensory and motor block produced by the spinal anaesthesia will be assessed prior the procedure to define readiness for surgery and then once the procedure is over, sensory and motor block levels will be assessed one more time to follow up the block regression times. Motor block will be assessed with Bromage scale (0: no motor block, 1: hip blocked; 2: hip and knee blocked; 3: hip, knee and ankle blocked). Sensory block will be assessed using loss of pinprick sensation. The onset of surgical anesthesia is defined as loss of pinprick sensation at ≥ T10 with a Bromage score ≥ 2. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| first mobilisation, first urination and first analgesic times | after the procedure, during the first 24 hours | all patients will be followed up during the first postoperative 24 hours to assess the first mobilisation, first voiding and first analgesic requirement times. |
Other
| Measure | Time frame | Description |
|---|---|---|
| postoperative nausea, vomiting and pruritus | after the procedure, during the first 24 hours | All patients will be followed up for the first postoperative 24 hours to determine the nausea, vomiting and pruritus incidences. |
Countries
Turkey (Türkiye)
Outcome results
None listed