Critically Ill
Conditions
Brief summary
In critical illness, patients are highly stressed and should have elevated cortisol (stress hormone) secretion to adapt to stress. Dysfunction of this system is referred to as critical illness-related corticosteroid insufficiency. Free cortisol (unbound form) which is mainly responsible for its physiologic function is difficult to measure. We hypothesized that the salivary cortisol, which can be obtained by noninvasive methods, can more accurately evaluate adrenal function of critically ill patients.
Interventions
OTHERSalivary cortisol test
Sponsors
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients who agreed to participate
Exclusion criteria
* Known adrenal or pituitary disease * oral bleeding * currently on systemic or inhaled corticosteroids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall mortality | 28 days |
Secondary
| Measure | Time frame |
|---|---|
| ICU days | 28 days |
| ventilator-free days | 28 days |
Countries
South Korea
Contacts
Primary ContactJinwoo Lee, M.D.
Outcome results
None listed