Vascular Function on the First Day After Cardiac Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02001090

Enrollment

Registered

2013-12-04

Start date

2013-12-31

Completion date

2014-04-29

Last updated

2017-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

Cardiac Surgical Procedures, Heart-Lung Machine, Coronary Artery Bypass, Brachial Artery, Vasodilation, Regional Blood Flow, Ultrasonography

Brief summary

This study examines the flow mediated dilation (FMD) of the brachial artery before and after cardiac surgery. FMD is measured with ultrasound technique. Increased flow is achieved trough obstructing blood flow with a cuff around the forearm for five minutes. FMD is measured before surgery and on the first morning after the operation.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Inclusion criteria

* admitted for coronary artery bypass surgery

Exclusion criteria

* Ongoing treatment with nitrates or RAAS inhibiting drugs * unstable coronary syndrome * unstable circulation/shock * renal failure * hepatic failure * autoimmune or inflammatory disease * untreated hypertension.

Design outcomes

Primary

Measure	Time frame	Description
flow mediated dilation of the brachial artery	one day	Transitory change in FMD as a consequence of cardiac surgery with use of extra corporal circulation.

Secondary

Measure	Time frame	Description
Reactive hyperemia	one day	Transitory change in reactive hyperemia after five minutes of occlusion of forearm blood flow as a consequence of cardiac surgery with the use of extra corporal circulation.

Countries

Norway

Outcome results