Dietary and Exercise Interventions in Preventing Cardiovascular Disease in Younger Survivors of Leukemia, Lymphoma, or Brain Tumors

Effect of Non-Pharmacologic Interventions on Risk Factors of Cardiovascular Disease in Survivors of Childhood Leukemia, Lymphoma and Brain Tumor

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02000986

Enrollment

Registered

2013-12-04

Start date

2012-08-31

Completion date

2015-07-31

Last updated

2015-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Childhood Brain Tumor, Childhood Hodgkin Lymphoma, Childhood Non-Hodgkin Lymphoma, Malignant Childhood Neoplasm

Keywords

Hodgkin's Lymphoma, Brain and Nervous System, Non-Hodgkin's Lymphoma, Leukemia, not otherwise specified

Brief summary

This clinical trial studies dietary and exercise interventions in preventing cardiovascular disease in younger survivors of childhood cancer. Eating a healthy diet and exercising regularly may reduce the risk of cardiovascular disease in younger survivors of childhood cancer.

Detailed description

Participants receive personalized exercise plan and prescription tailored to individual needs and current level of activity and fitness, and they also receive 2 one-hour individual exercise training sessions consisting of 20-30 minutes cardiovascular activity and strength training. Participants receive nutritional education consisting of energy balance, appropriate portion sizes, calorie count, and basic nutrition skills such as label reading every 2 weeks for 12 weeks. After completion of study treatment, patients are followed for up to 6 months.

Interventions

BEHAVIORALSpecimen Collection/Risk Factor Assessment -> Diet/Exercise -> Chemotherapy

Participants will be taught by a registered dietician about energy balance and how body weight relates to energy intake and expenditure, although specific calorie prescriptions will not be given. An exercise physiologist will create a personalized exercise plan and prescription which is tailored to his / her needs and current level of activity and fitness

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

11 Years to 17 Years

Healthy volunteers

Inclusion criteria

* Diagnosis of pediatric cancer * Patients 3 months to 1 year after completion of therapy

Exclusion criteria

* Patients who are already on antihypertensive or insulin or cholesterol lowering medication * Patients who have not been evaluated for exercise tolerance and cleared by their physician for participation * Inability to understand program instructions due to language barrier or mental disability * Unable to participate in the outlined exercise program due to a physical disability

Design outcomes

Primary

Measure	Time frame	Description
Feasibility determined by average attendance and retention	At 3 months	Acceptability will be determined by responses on feedback measures and qualitative analysis of exit interviews.

Secondary

Measure	Time frame	Description
Feasibility determined by average attendance and retention from the blood pressure at enrollment	At 6 months	Will be assessed via paired T test.
Acceptability level at time of enrollment	At 6 months	Acceptability will be determined by responses on feedback measures and qualitative analysis of exit interviews.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026