Succinylcholine vs Rocuronium for Prehospital Emergency Intubation

Succinylcholine vs Rocuronium for Prehospital Emergency Intubation : a Randomized Trial

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02000674

Acronym

CURASMUR

Enrollment

1321

Registered

2013-12-04

Start date

2013-12-31

Completion date

2016-07-31

Last updated

2017-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coma, Major Trauma, Respiratory Distress, Shock

Keywords

tracheal intubation, pre hospital emergency

Brief summary

All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context will be included in order to compare the use of succinylcholine vs Rocuronium for prehospital emergency intubation.

Detailed description

All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context will be included. All intubation will be performed by an emergency physician or a nurse specialized in anesthesia. For patients with spontaneous cardiac activity, rapid sequence intubation will be performed to allow intubation. Comparisons studied will be : Intubation success rate at the first laryngoscopy, glottis exposure assessed by Cormack and Lehane classification, difficult intubation rate assessed by the Intubation Difficult Score (IDS), the conditions of intubation assessed by the Copenhagen score, the need for alternative airway techniques and the immediate post intubation complications rate as vomiting, dental trauma, pulmonary inhalation, arterial desaturation , hypotension episodes and cardiac arrest occurrence.

Interventions

DRUGSuccinylcholine : 1mg/kg

DRUGRocuronium : 1.2 mg/kg

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context

Exclusion criteria

* Patients in cardiac arrest; * Patients under-18s; * Patients under guardianship ; * Pregnancy known; * Patients with cons to one of the following three drugs: rocuronium, succinylcholine, sugammadex; * Patients not affiliated to a social security scheme (beneficiary or legal).

Design outcomes

Primary

Measure	Time frame	Description
First-pass intubation success rate	between 1 hour to 3 hours after inclusion	Measured by the proportion of successful intubation in the first laryngoscopy.

Secondary

Measure	Time frame	Description
Incidence of difficult intubation	between 1 hour to 3 hours after inclusion	measured by the Intubation Difficulty Scale
Intubation conditions assessment	between 1 hour to 3 hours after inclusion	using the Copenhagen score
Need for alternate airway devices	between 1 hour to 3 hours after inclusion	—
early intubation-related complications	between 1 hour to 3 hours after inclusion	complications : esophageal intubation, mainstem intubation, vomiting, pulmonary aspiration, dental trauma, bronchospasm or laryngospasm, ventricular tachycardia, arterial desaturation, hypotension, or cardiac arrest

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 19, 2026