Allergic Rhinitis, Chronic Urticaria, Non-allergic Rhinitis
Conditions
Keywords
Allergic Rhinitis, Non-allergic Rhinitis, Chronic urticaria
Brief summary
Observation study of patients with chronic rhinitis or chronic urticaria in Thailand
Detailed description
All patients presenting with symptoms of chronic rhinitis for at least 12 consecutive or non-consecutive weeks per years or symptoms of chronic urticaria for at least 6 weeks will be asked to complete the case report forms asking for details of symptom characteristics, risk factors, personal habits, underlying diseases, and quality of life at the first visit. Investigation results, final diagnosis, and therapeutic interventions will also be recorded by the responsible allergist. On every follow-up appointment, patient symptoms, aggravating factors, medication use and side effects will be completed by patients. New findings, associated diseases, and prescriptions will be completed by allergist. The unfilled variables by patients will be asked in the following visit. Any non-reported variables those are unable to retrieve will be treated as missing data for data analysis. The estimated sample size is about 200 new cases per year. Patient demographic data, clinical presentations, and associated diseases will be reported. The association between clinical characteristics and quality of life will be analyzed. The relationship between clinical manifestations and therapeutic outcomes will be determined.
Interventions
None listed
Sponsors
Chulalongkorn University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Have symptoms of chronic rhinitis for at least 12 consecutive or non-consecutive weeks per year or symptoms of chronic urticaria for at least 6 weeks
Exclusion criteria
* Less than 15 years of age
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The recalcitrant symptoms of chronic rhinitis or chronic urticaria | Baseline and 2 months after treatment | The alteration of symptoms at 2 months compared to baseline. Patient's complaining symptoms will be graded as likert scale system (0, 1, 2, 3). Any symptoms at 2 months after treatment that decrease less than 25% from base line based on average likert scale will be defined as recalcitrant. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The correlation between symptom severity and quality of life | At baseline | Pearson correlation between total nasal symptom score in patients with rhinitis or urticaria activity score in patients with chronic urticaria and 12-item short form survey version 2 (SF-12 v2) will be analyzed |
Other
| Measure | Time frame | Description |
|---|---|---|
| Factors affecting therapeutic outcome (composite outcome measure) | At baseline | Multivariate analysis will be analyzed between age group, gender, allergic status, symptom severity and the magnitude of symptom alteration at 2 months after treatment |
Countries
Thailand
Outcome results
None listed