Early Enteral Nutrition in Severe Acute Pancreatitis

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02000323

Enrollment

Registered

2013-12-04

Start date

2012-08-31

Completion date

2017-08-31

Last updated

2013-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatitis

Keywords

pancreatitis, enteral nutrition

Brief summary

to compare different time points for enteral nutrition in SAP patients

Detailed description

There is increasing evidence that indicates Early Enteral Nutrition（EEN） may be associated with improved outcome in acute pancreatitis patients. However, some SAP patients failed to EEN. The researchers of this study aim to investigate the opportunity of EEN on the clinical outcomes of SAP patients.

Interventions

OTHERearly enteral nutrition

Naso-gastro-jejunal tube will be set up by X-ray within 24 hours of admission. The distal end of the feeding tube would be placed at the remote end of Treitz ligament, and verified by X-ray. • After catharsis, Standard enteral nutrition liquid regimen will be used step by step. Patients are targeted to receive calories for 25 kcal/kg/day. nutrition form: short peptide ,1 kcal/ml,target 200k kcal/day

OTHERmodified early enteral nutrition

Naso-gastro-jejunal tube will be set up by X-ray within 24 hours of admission. * The distal end of the feeding tube would be placed at the remote end of Treitz ligament, and verified by X-ray. * After catharsis, Only Normal Saline were given through nasojejunal tube until 2 or more followed requirements were meted (mean arterial pressure≥65mmHg; oxygenation index≥ 300;APCHEII≤8; intra-abdominal pressure \<20mmHg).Then Standard enteral nutrition liquid regimen (Peptisorb Liquid) will be used step by step. * Patients are targeted to receive calories for 25 kcal/kg/day.

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

1. Diagnosis of pancreatitis: Typical pain increase in serum lipase or amylase 2. Onset of abdominal pain within \<=72h before admission 3. moderate severe or severe Acute Pancreatitis according to Atlanta criteria revisited in 2012 ffff

Exclusion criteria

* 1\. Pregnancy 2.tumor 3. acute onset of chronic pancreatitis 4. chronic disease of any organ （heart lung gastrointestinal renal etc.） 5. Pre-existing disease with life expectancy \< 3 months 7.receive parenteral nutrition or enteral nutrition before admitting

Design outcomes

Primary

Measure	Time frame	Description
mortality	28days	the rate of patients died

Secondary

Measure	Time frame	Description
operation rate	2 months	The rate of patients received operation for pancreatitis debridement
fulfilling enteral nutrition target（≥25Kcal/kg/day）	7 days	enteral nutrition target set as ≥25Kcal/kg/day

Other

Measure	Time frame
inta-abdominal infection	2 months

Countries

China

Contacts

Primary ContactZhen Er chen, PHD

chenerzhen@hotmail.com64370045

Backup Contactqiang En mao

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026