Sleep Deprivation
Conditions
Keywords
Sleep, resting state, functional connectivity, emotional contagion, empathy, emotional regulation
Brief summary
The main purpose of this study is to investigate the effects of partial sleep deprivation (PSD) on resting state brain connectivity, emotional contagion, empathy, and emotional regulation.
Interventions
BEHAVIORALPartial sleep deprivation allowing 3 h sleep at night
Participants sleep at home while monitored with ambulatory polysomnography. For the full sleep condition, they are instructed to go to bed and to get up at the usual times that they would normally do that. For the sleep deprivation condition, they are instructed to go to bed 3 hours before the time when they would usually get up, and then to get up at that time.
BEHAVIORALFull sleep
Participants sleep at home while monitored with ambulatory polysomnography. For the full sleep condition, they are instructed to go to bed and to get up at the usual times that they would normally do that. For the sleep deprivation condition, they are instructed to go to bed 3 hours before the time when they would usually get up, and then to get up at that time.
Sponsors
Stockholm University
Mats Lekander
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* 20-30 years of age, inclusive OR 65-75 years of age, inclusive * Able to understand spoken and written Swedish (in order to understand instructions) * Normal or corrected-to-normal vision not using glasses * Not colour blind * Right-handed * Free from ferromagnetic objects in body * No history of any neurologic or psychiatric illness including drug abuse * No history of diabetes nor hypertension * No depression according to ratings using the Hospital Anxiety and Depression scale (HAD) * No insomnia according to ratings using the Insomnia Severity Index (ISI) and Karolinska Sleep Questionnaire (KSQ) * No use of psychotropic drugs * Not studying or working in medicine, psychology, nor behavioural science * Not suffering from severe seasonal allergy * No use of cortisone, anti-histamines, nor any other immune-modulating drugs * Habitual intake of no more than 4 cups of coffee per day or the equivalent in terms of caffeine * No daily use of nicotine
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood oxygen level-dependent response in amygdala to angry faces (t/z-score from statistical parametric mapping) | Change between 1st and 2nd MRI scanning session (approx. 1 month later) | This registration is made in order to pre-specify hypotheses in a basic science project. For a full list of outcomes and hypotheses, see study description (above). |
Countries
Sweden
Outcome results
None listed